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Article

Induction of HEXIM1 activities by HMBA derivative 4a1: Functional consequences and mechanism.

Cancer letters - 28 Aug 2016

Ketchart Wannarasmi, Yeh I-Ju, Zhou Haoyan, Thiagarajan Praveena S, Lathia Justin, Reizes Ofer, Exner Agata, Su Bin, Montano Monica M

Abstract excerpt

We have been studying the role of Hexamethylene bisacetamide (HMBA) Induced Protein 1 (HEXIM1) as a tumor suppressor whose expression is decreased in tamoxifen resistant and metastatic breast cancer. HMBA was considered the most potent and specific inducer for HMBA inducible protein 1 (HEXIM1) prior to our studies. Moreover, the ability of HMBA to induce differentiation is advantageous for its therapeutic use...

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Source

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Identifiers

PMID: 27238569
DOI: 10.1016/j.canlet.2016.05.029
PMCID: PMC4988685

Genes

HEXIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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