Article
Gene-gene and gene-sex epistatic interactions of DNMT1, DNMT3A and DNMT3B in autoimmune thyroid disease.
Endocrine journal - 30 Jul 2016
Cai Tian-Tian, Zhang Jian, Wang Xuan, Song Rong-Hua, Qin Qiu, Muhali Fatuma-Said, Zhou Jiao-Zhen, Xu Jian, Zhang Jin-An
Abstract excerpt
The aim of this study was to investigate the associations of DNA methyltransferases (DNMTs) polymorphisms with susceptibility to autoimmune thyroid diseases (AITDs) and to test gene-gene/gene-sex epistasis interactions. Eight single-nucleotide polymorphisms (SNPs) in DNMT1, DNMT3A and DNMT3B were selected and genotyped by multiplex polymerase chain reaction combined with ligase detection reaction method...
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