Article
Rare intronic variants of TCF7L2 arising by selective sweeps in an indigenous population from Mexico.
BMC genetics - 26 May 2016
Acosta Jose Luis, Hernández-Mondragón Alma Cristal, Correa-Acosta Laura Carolina, Cazañas-Padilla Sandra Nathaly, Chávez-Florencio Berenice, Ramírez-Vega Elvia Yamilet, Monge-Cázares Tulia, Aguilar-Salinas Carlos A, Tusié-Luna Teresa, Del Bosque-Plata Laura
Abstract excerpt
BACKGROUND: Genetic variations of the TCF7L2 gene are associated with the development of Type 2 diabetes (T2D). The associated mutations have demonstrated an adaptive role in some human populations, but no studies have determined the impact of evolutionary forces on genetic diversity in indigenous populations from Mexico. Here, we sequenced and analyzed the variation of the TCF7L2 gene in three Amerindian...
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