Article
Accurate detection for a wide range of mutation and editing sites of microRNAs from small RNA high-throughput sequencing profiles.
Nucleic acids research - 19 Aug 2016
Zheng Yun, Ji Bo, Song Renhua, Wang Shengpeng, Li Ting, Zhang Xiaotuo, Chen Kun, Li Tianqing, Li Jinyan
Abstract excerpt
Various types of mutation and editing (M/E) events in microRNAs (miRNAs) can change the stabilities of pre-miRNAs and/or complementarities between miRNAs and their targets. Small RNA (sRNA) high-throughput sequencing (HTS) profiles can contain many mutated and edited miRNAs. Systematic detection of miRNA mutation and editing sites from the huge volume of sRNA HTS profiles is computationally difficult, as high...
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