Article
Fam83h mutation inhibits the mineralization in ameloblasts by activating Wnt/β-catenin signaling pathway.
Biochemical and biophysical research communications - 18 Jun 2018
Yang Mei, Huang Wushuang, Yang Fang, Zhang Tingting, Wang Changning, Song Yaling
Abstract excerpt
FAM83H was identified as the major causative gene for autosomal dominant hypocalcified amelogenesis imperfect (ADHCAI). The pathogenic mechanism of FAM83H in ADHCAI remains elusive. The present study aims to investigate the effect of Fam83h mutation on the mineralization of mouse ameloblast cell line LS8 and to explore the possible pathogenesis of ADHCAI. Lentivirus package was performed for the plasmids with...
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