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Article

Transcription factor TLX1 controls retinoic acid signaling to ensure spleen development.

The Journal of clinical investigation - 1 Jul 2016

Lenti Elisa, Farinello Diego, Yokoyama Kazunari K, Penkov Dmitry, Castagnaro Laura, Lavorgna Giovanni, Wuputra Kenly, Sandell Lisa L, Tjaden Naomi E Butler, Bernassola Francesca, Caridi Nicoletta, De Antoni Anna, Wagner Michael, Kozinc Katja, Niederreither Karen, Blasi Francesco, Pasini Diego, Majdic Gregor, Tonon Giovanni, Trainor Paul A, Brendolan Andrea

Abstract excerpt

The molecular mechanisms that underlie spleen development and congenital asplenia, a condition linked to increased risk of overwhelming infections, remain largely unknown. The transcription factor TLX1 controls cell fate specification and organ expansion during spleen development, and Tlx1 deletion causes asplenia in mice. Deregulation of TLX1 expression has recently been proposed in the pathogenesis of...

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Identifiers

PMID: 27214556
DOI: 10.1172/JCI82956
PMCID: PMC4922703

Genes

TLX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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