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Article

An asparagine residue mediates intramolecular communication in nucleotide-regulated pyrophosphatase.

The Biochemical journal - 15 Jul 2016

Anashkin Viktor A, Salminen Anu, Vorobjeva Natalia N, Lahti Reijo, Baykov Alexander A

Abstract excerpt

Many prokaryotic soluble PPases (pyrophosphatases) contain a pair of regulatory adenine nucleotide-binding CBS (cystathionine β-synthase) domains that act as 'internal inhibitors' whose effect is modulated by nucleotide binding. Although such regulatory domains are found in important enzymes and transporters, the underlying regulatory mechanism has only begun to come into focus. We reported previously that CBS...

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Identifiers

PMID: 27208172
DOI: 10.1042/BCJ20160293

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CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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