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Article

A combined laser microdissection and mass spectrometry approach reveals new disease relevant proteins accumulating in aggregates of filaminopathy patients.

Molecular & cellular proteomics : MCP - 1 Jan 2013

Kley Rudolf A, Maerkens Alexandra, Leber Yvonne, Theis Verena, Schreiner Anja, van der Ven Peter F M, Uszkoreit Julian, Stephan Christian, Eulitz Stefan, Euler Nicole, Kirschner Janbernd, Müller Klaus, Meyer Helmut E, Tegenthoff Martin, Fürst Dieter O, Vorgerd Matthias, Müller Thorsten, Marcus Katrin

Abstract excerpt

Filaminopathy is a subtype of myofibrillar myopathy caused by mutations in FLNC, the gene encoding filamin C, and histologically characterized by pathologic accumulation of several proteins within skeletal muscle fibers. With the aim to get new insights in aggregate composition, we collected aggr...

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Identifiers

PMID: 23115302
DOI: 10.1074/mcp.M112.023176
PMCID: PMC3536902

Genes

FLNC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23115302-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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