Standard Genotyping Overestimates Transmission of Mycobacterium tuberculosis among Immigrants in a Low-Incidence Country.

doi:10.1128/JCM.00126-16

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Article

Standard Genotyping Overestimates Transmission of Mycobacterium tuberculosis among Immigrants in a Low-Incidence Country.

Journal of clinical microbiology - 1 Jul 2016

Stucki David, Ballif Marie, Egger Matthias, Furrer Hansjakob, Altpeter Ekkehardt, Battegay Manuel, Droz Sara, Bruderer Thomas, Coscolla Mireia, Borrell Sonia, Zürcher Kathrin, Janssens Jean-Paul, Calmy Alexandra, Mazza Stalder Jesica, Jaton Katia, Rieder Hans L, Pfyffer Gaby E, Siegrist Hans H, Hoffmann Matthias, Fehr Jan, Dolina Marisa, Frei Reno, Schrenzel Jacques, Böttger Erik C, Gagneux Sebastien, Fenner Lukas

Abstract excerpt

Immigrants from regions with a high incidence of tuberculosis (TB) are a risk group for TB in low-incidence countries such as Switzerland. In a previous analysis of a nationwide collection of 520 Mycobacterium tuberculosis isolates from 2000 to 2008, we identified 35 clusters comprising 90 patients based on standard genotyping (24-locus mycobacterial interspersed repetitive-unit-variable-number tandem-repeat...

Topics

Adolescent
Adult
Cluster Analysis
Disease Transmission, Infectious
Emigrants and Immigrants
Female
Follow-Up Studies
Genome, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Incidence

Male

Middle Aged

Molecular Epidemiology

Molecular Typing

Mycobacterium tuberculosis

Polymorphism, Single Nucleotide

Sequence Analysis, DNA

Switzerland

Source

Open in PubMed Open full text

Identifiers

PMID: 27194683
DOI: 10.1128/JCM.00126-16
PMCID: PMC4922098

Provenance

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