Article
HCV inter-subtype 1a/1b recombinant detected by complete-genome next-generation sequencing.
Archives of virology - 1 Aug 2016
Gaspareto Karine Vieira, Ribeiro Roberto Marques, de Mello Malta Fernanda, Gomes-Gouvêa Michele Soares, Muto Nair Hideko, Mendes-Correa Maria Cassia, Rozanski Andrei, Carrilho Flair José, Sabino Ester Cerdeira, Pinho João Renato Rebello
Abstract excerpt
Next-generation sequencing (NGS) provides a practical approach to HCV complete-genome sequencing, detecting low-frequency variants and allowing analysis of viral genetic diversity (quasispecies) in the sample, and so far, it is very useful for identifying preexisting drug-resistant mutants and emerging escape mutations, as well as detecting viral recombinants containing genomic regions from different genotypes...
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