Article
A Simple, General Result for the Variance of Substitution Number in Molecular Evolution.
Molecular biology and evolution - 1 Jul 2016
Houchmandzadeh Bahram, Vallade Marcel
Abstract excerpt
The number of substitutions (of nucleotides, amino acids, etc.) that take place during the evolution of a sequence is a stochastic variable of fundamental importance in the field of molecular evolution. Although the mean number of substitutions during molecular evolution of a sequence can be estimated for a given substitution model, no simple solution exists for the variance of this random variable. We show in...
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