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Article

Utilizing a TLR5-Adjuvanted Cytomegalovirus as a Lentiviral Vaccine in the Nonhuman Primate Model for AIDS.

PloS one - 1 Jan 2016

Deere Jesse D, Chang W L William, Castillo Luis D, Schmidt Kim A, Kieu Hung T, Renzette Nicholas, Kowalik Timothy, Barthold Stephen W, Shacklett Barbara L, Barry Peter A, Sparger Ellen E

Abstract excerpt

Despite tremendous progress in our understanding of human immunodeficiency virus (HIV) natural history and advances in HIV treatment, there is neither an approved vaccine nor a cure for infection. Here, we describe the development and characterization of a novel replicating vaccine vector utilizing Cytomegalovirus (CMV) and a TLR5 adjuvant. After partial truncation of the central, immunodominant hypervariable...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Gene Products, gag

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Share to Simian Acquired Immunodeficiency Syndrome

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Source

Open in PubMed Open full text

Identifiers

PMID: 27182601
DOI: 10.1371/journal.pone.0155629
PMCID: PMC4868283

Genes

TLR5
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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