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Article

Fibroblast spheroids as a model to study sustained fibroblast quiescence and their crosstalk with tumor cells.

Experimental cell research - 1 Jul 2016

Salmenperä Pertteli, Karhemo Piia-Riitta, Räsänen Kati, Laakkonen Pirjo, Vaheri Antti

Abstract excerpt

Stromal fibroblasts have an important role in regulating tumor progression. Normal and quiescent fibroblasts have been shown to restrict and control cancer cell growth, while cancer-associated, i. e. activated fibroblasts have been shown to enhance proliferation and metastasis of cancer cells. In this study we describe generation of quiescent fibroblasts in multicellular spheroids and their effects on squamous...

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PMID: 27177832
DOI: 10.1016/j.yexcr.2016.05.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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