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Article

A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett’s Esophagus

11 May 2016

Abstract excerpt

Biomarkers that drift differentially with age between normal and premalignant tissues, such as Barrett's esophagus (BE), have the potential to improve the assessment of a patient's cancer risk by providing quantitative information about how long a patient has lived with the precursor (i.e., dwell time). In the case of BE, which is a metaplastic precursor to esophageal adenocarcinoma (EAC), such biomarkers would...

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PMID: 27168458
DOI: 10.1371/journal.pcbi.1004919

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