Article
The Wilms' tumor (WT1) gene expression correlates with the International Prognostic Scoring System (IPSS) score in patients with myelofibrosis and it is a marker of response to therapy.
Cancer medicine - 1 Jul 2016
Gallo Daniela, Nicoli Paolo, Calabrese Chiara, Gaidano Valentina, Petiti Jessica, Rosso Valentina, Signorino Elisabetta, Carturan Sonia, Bot-Sartor Giada, Volpe Gisella, Frassoni Francesco, Saglio Giuseppe, Cilloni Daniela
Abstract excerpt
The Wilms tumor gene WT1 is a useful marker of clonal hematopoiesis and it has been shown to be a good marker of residual disease and it reflects the response to therapy. Although myelofibrosis is characterized by mutations of JAK2 and calreticulin (CALR), these mutations are not useful to monitor response to therapy. In this study we demonstrated that in patients affected by myelofibrosis WT1 correlates with the...
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