Prospective Analysis of Oncogenic Driver Mutations and Environmental Factors: Japan Molecular Epidemiology for Lung Cancer Study.

doi:10.1200/JCO.2015.64.2322

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Article

Prospective Analysis of Oncogenic Driver Mutations and Environmental Factors: Japan Molecular Epidemiology for Lung Cancer Study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 1 Jul 2016

Kawaguchi Tomoya, Koh Yasuhiro, Ando Masahiko, Ito Norimasa, Takeo Sadanori, Adachi Hirofumi, Tagawa Tsutomu, Kakegawa Seiichi, Yamashita Motohiro, Kataoka Kazuhiko, Ichinose Yukito, Takeuchi Yukiyasu, Serizawa Masakuni, Tamiya Akihiro, Shimizu Shigeki, Yoshimoto Naoki, Kubo Akihito, Isa Shun-Ichi, Saka Hideo, Matsumura Akihide

Abstract excerpt

PURPOSE: Oncogenic driver mutations are critical for lung cancer development and serve as therapeutic targets. However, their associations with environmental factors are not fully understood. We aimed to elucidate the relationship between tumor developmental biology and exposure to environmental factors. PATIENTS AND METHODS: This was a prospective, multicenter, molecular epidemiology study. Eligible patients...

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PMID: 27161973
DOI: 10.1200/JCO.2015.64.2322

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EGFR
KRAS
SMAD4

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