Article
Immune signatures and disorder-specific patterns in a cross-disorder gene expression analysis.
The British journal of psychiatry : the journal of mental science - 1 Sept 2016
de Jong Simone, Newhouse Stephen J, Patel Hamel, Lee Sanghyuck, Dempster David, Curtis Charles, Paya-Cano Jose, Murphy Declan, Wilson C Ellie, Horder Jamie, Mendez M Andreina, Asherson Philip, Rivera Margarita, Costello Helen, Maltezos Stefanos, Whitwell Susannah, Pitts Mark, Tye Charlotte, Ashwood Karen L, Bolton Patrick, Curran Sarah, McGuffin Peter, Dobson Richard, Breen Gerome
Abstract excerpt
BACKGROUND: Recent studies point to overlap between neuropsychiatric disorders in symptomatology and genetic aetiology. AIMS: To systematically investigate genomics overlap between childhood and adult attention-deficit hyperactivity disorder (ADHD), autism spectrum disorder (ASD) and major depressive disorder (MDD). METHOD: Analysis of whole-genome blood gene expression and genetic risk scores of 318 individuals....
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