Article
Urine Exosomes for Non-Invasive Assessment of Gene Expression and Mutations of Prostate Cancer.
PloS one - 1 Jan 2016
Motamedinia Piruz, Scott Anna N, Bate Kendall L, Sadeghi Neda, Salazar Guillermo, Shapiro Edan, Ahn Jennifer, Lipsky Michael, Lin James, Hruby Greg W, Badani Ketan K, Petrylak Daniel P, Benson Mitchell C, Donovan Michael J, Comper Wayne D, McKiernan James M, Russo Leileata M
Abstract excerpt
PURPOSE: The analysis of exosome/microvesicle (extracellular vesicles (EVs)) and the RNA packaged within them (exoRNA) has the potential to provide a non-invasive platform to detect and monitor disease related gene expression potentially in lieu of more invasive procedures such as biopsy. However, few studies have tested the diagnostic potential of EV analysis in humans. EXPERIMENTAL DESIGN: The ability of EV...
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