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Prostate cancer reshapes the secreted and extracellular vesicle urinary proteomes

13 Jun 2024

Abstract excerpt

Urine is a complex biofluid that reflects both overall physiologic state and the state of the genitourinary tissues through which it passes. It contains both secreted proteins and proteins encapsulated in tissue-derived extracellular vesicles (EVs). To understand the population variability and clinical utility of urine, we quantified the secreted and EV proteomes from 190 men, including a subset with prostate...

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PMID: 38871730
DOI: 10.1038/s41467-024-49424-5

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