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Article

Whole-Exome Molecular Autopsy After Exertion-Related Sudden Unexplained Death in the Young.

Circulation. Cardiovascular genetics - 1 Jun 2016

Anderson Jason H, Tester David J, Will Melissa L, Ackerman Michael J

Abstract excerpt

BACKGROUND: Targeted postmortem genetic testing of the 4 major channelopathy-susceptibility genes (KCNQ1, KCNH2, SCN5A, and RYR2) have yielded putative pathogenic mutations in ≤30% of autopsy-negative sudden unexplained death in the young (SUDY) cases with highest yields derived from the subset of exertion-related SUDY. Here, we evaluate the role of whole-exome sequencing in exertion-related SUDY cases. METHODS...

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Source

Identifiers

PMID: 27114410
DOI: 10.1161/CIRCGENETICS.115.001370

Genes

CALM2
KCNH2
KCNQ1
RYR2
PKP2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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