Article
Mutation specific immunohistochemistry is highly specific for the presence of calreticulin mutations in myeloproliferative neoplasms.
Pathology - 1 Jun 2016
Andrici Juliana, Farzin Mahtab, Clarkson Adele, Sioson Loretta, Sheen Amy, Watson Nicole, Toon Christopher W, Koleth Mary, Stevenson William, Gill Anthony J
Abstract excerpt
The identification of somatic calreticulin (CALR) mutations can be used to confirm the diagnosis of a myeloproliferative disorder in Philadelphia chromosome-negative, JAK2 and MPL wild type patients with thrombocytosis. All pathogenic CALR mutations result in an identical C-terminal protein and therefore may be identifiable by immunohistochemistry. We sought to test the sensitivity and specificity of mutation...
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