Article
Mutant specific anti calreticulin antibody (CAL2) immunohistochemistry as a screening test for calreticulin (CALR) mutation testing.
International journal of laboratory hematology - 1 Oct 2020
Rahman Khaliqur, Chandra Dinesh, Singh Manish Kumar, Gupta Ruchi, Sharma Akhilesh, Paul Pradeep, Kumar Sanjeev, Sharma Seema, Nityanand Soniya
Abstract excerpt
BACKGROUND: About 50 different CALR frameshift mutations have been identified in BCR-ABL1 negative MPN, all leading to the development of common new protein C terminus. Antibody targeting this terminal epitope can be useful to identify this driver mutation using immunohistochemistry. MATERIALS AND METHODS: CALR mutation analysis was carried out in 51 JAK2V617F negative cases, PMF (n = 22) and ET (n = 29). PCR...
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