Article
X chromosome-wide identification of SNVs in microRNA genes and non-obstructive azoospermia risk in Han Chinese population.
Oncotarget - 2 Aug 2016
Ji Juan, Qin Yufeng, Zhou Ran, Zang Rujin, Huang Zhenyao, Zhang Yan, Chen Minjian, Wu Wei, Song Ling, Ling Xiufeng, Shen Hongbing, Hu Zhibin, Xia Yankai, Lu Chuncheng, Wang Xinru
Abstract excerpt
Human X chromosome has higher densities of microRNAs (miRNAs) compared to the average densities on autosomes. Given that numbers of X-linked miRNAs can escape from meiotic sex chromosome inactivation (MSCI) silencing, it is proposed that X-linked miRNAs may play critical roles in the process of spermatogenesis. To test the hypothesis, we performed DNA capture sequencing of human X-linked miRNAs, which was...
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