Article
Helminth infection promotes colonization resistance via type 2 immunity.
Science (New York, N.Y.) - 29 Apr 2016
Ramanan Deepshika, Bowcutt Rowann, Lee Soo Ching, Tang Mei San, Kurtz Zachary D, Ding Yi, Honda Kenya, Gause William C, Blaser Martin J, Bonneau Richard A, Lim Yvonne A L, Loke P'ng, Cadwell Ken
Abstract excerpt
Increasing incidence of inflammatory bowel diseases, such as Crohn's disease, in developed nations is associated with changes to the microbial environment, such as decreased prevalence of helminth colonization and alterations to the gut microbiota. We find that helminth infection protects mice deficient in the Crohn's disease susceptibility gene Nod2 from intestinal abnormalities by inhibiting colonization by an...
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