Article
Identification of benzopyrone as a common structural feature in compounds with anti-inflammatory activity in a zebrafish phenotypic screen.
Disease models & mechanisms - 1 Jun 2016
Robertson Anne L, Ogryzko Nikolay V, Henry Katherine M, Loynes Catherine A, Foulkes Matthew J, Meloni Marco M, Wang Xingang, Ford Christopher, Jackson Malcolm, Ingham Philip W, Wilson Heather L, Farrow Stuart N, Solari Roberto, Flower Roderick J, Jones Simon, Whyte Moira K B, Renshaw Stephen A
Abstract excerpt
Neutrophils are essential for host defence and are recruited to sites of inflammation in response to tissue injury or infection. For inflammation to resolve, these cells must be cleared efficiently and in a controlled manner, either by apoptosis or reverse migration. If the inflammatory response is not well-regulated, persistent neutrophils can cause damage to host tissues and contribute to the pathogenesis of...
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