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Article

A Functional Variant rs6435156C > T in BMPR2 is Associated With Increased Risk of Chronic Obstructive Pulmonary Disease (COPD) in Southern Chinese Population.

EBioMedicine - 1 Mar 2016

Wang Jian, Zhang Chenting, Zhang Zili, Zheng Zeguang, Sun Dejun, Yang Quan, Hadadi Cyrus, Li Defu, Xu Xiaoming, Xiong Mingmei, Zhou Qipeng, Guo Meihua, Wang Yingfeng, Tang Chun, Xu Guihua, Yang Kai, Zhong Nanshan, Lu Wenju

Abstract excerpt

BACKGROUNDS: Bone morphogenetic protein receptor type 2 (BMPR2) signaling is anti-inflammatory. Decreased BMPR2 expression was seen in lung tissue from chronic obstructive pulmonary disease (COPD) patients. METHODS: The selected single nucleotide polymorphisms (SNPs) in BMPR2 were genotyped with polymerase chain reaction (PCR) ligase detection reaction. The effects of SNPs on gene expression were analyzed with...

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Identifiers

PMID: 27077124
DOI: 10.1016/j.ebiom.2016.02.004
PMCID: PMC4816816

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BMPR2

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