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Dynamics of sterol synthesis during development of Leishmania spp. parasites to their virulent form

12 Apr 2016

Abstract excerpt

BACKGROUND: The Leishmania spp. protozoa, the causative agents of the "neglected" tropical disease leishmaniasis, are transmitted to mammals by sand fly vectors. Within the sand fly, parasites transform from amastigotes to procyclic promastigotes, followed by development of virulent (metacyclic) promastigote forms. The latter are infectious to mammalian hosts. Biochemical components localized in the parasite...

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PMID: 27071464
DOI: 10.1186/s13071-016-1470-0

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