Article
Complex Copy Number Variation of AMY1 does not Associate with Obesity in two East Asian Cohorts.
Human mutation - 1 Jul 2016
Yong Rita Y Y, Mustaffa Su'Aidah B, Wasan Pavandip S, Sheng Liang, Marshall Christian R, Scherer Stephen W, Teo Yik-Ying, Yap Eric P H
Abstract excerpt
The human amylase gene locus at chromosome 1p21.1 is structurally complex. This region contains two pancreatic amylase genes, AMY2B, AMY2A, and a salivary gene AMY1. The AMY1 gene harbors extensive copy number variation (CNV), and recent studies have implicated this variation in adaptation to starch-rich diets and in association to obesity for European and Asian populations. In this study, we showed that by...
Topics
- Adolescent
- Asian People
- Body Mass Index
- Case-Control Studies
- China
- DNA Copy Number Variations
- Genetic Association Studies
- Genetic Predisposition to Disease
- Humans
- Malaysia
- Obesity
- Pancreatic alpha-Amylases
- Polymerase Chain Reaction
- Salivary alpha-Amylases