Low copy number of the salivary amylase gene predisposes to obesity.

doi:10.1038/ng.2939

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Article

Low copy number of the salivary amylase gene predisposes to obesity.

Nature genetics - 1 May 2014

Falchi Mario, El-Sayed Moustafa Julia Sarah, Takousis Petros, Pesce Francesco, Bonnefond Amélie, Andersson-Assarsson Johanna C, Sudmant Peter H, Dorajoo Rajkumar, Al-Shafai Mashael Nedham, Bottolo Leonardo, Ozdemir Erdal, So Hon-Cheong, Davies Robert W, Patrice Alexandre, Dent Robert, Mangino Massimo, Hysi Pirro G, Dechaume Aurélie, Huyvaert Marlène, Skinner Jane, Pigeyre Marie, Caiazzo Robert, Raverdy Violeta, Vaillant Emmanuel, Field Sarah, Balkau Beverley, Marre Michel, Visvikis-Siest Sophie, Weill Jacques, Poulain-Godefroy Odile, Jacobson Peter, Sjostrom Lars, Hammond Christopher J, Deloukas Panos, Sham Pak Chung, McPherson Ruth, Lee Jeannette, Tai E Shyong, Sladek Robert, Carlsson Lena M S, Walley Andrew, Eichler Evan E, Pattou Francois, Spector Timothy D, Froguel Philippe

Abstract excerpt

Common multi-allelic copy number variants (CNVs) appear enriched for phenotypic associations compared to their biallelic counterparts. Here we investigated the influence of gene dosage effects on adiposity through a CNV association study of gene expression levels in adipose tissue. We identified significant association of a multi-allelic CNV encompassing the salivary amylase gene (AMY1) with body mass index (BMI)...

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Identifiers

PMID: 24686848
DOI: 10.1038/ng.2939
PMCID: PMC6485469

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