The Sperm TRP-3 Channel Mediates the Onset of a Ca2+ Wave in the Fertilized C. elegans Oocyte

Abstract excerpt

Sperm induce Ca(2+) waves in the fertilized egg by introducing soluble factors or by surface interactions, which activate egg Ca(2+) channels. Involvement of sperm Ca(2+) channels is predicted by the conduit model; however, this model has not been validated. In Caenorhabditis elegans, the sperm-specific TRP family Ca(2+) channel TRP-3 mediates sperm-oocyte fusion. Here, using high-speed in vivo imaging and image...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Circadian rhythm and melatonin
• Share to Genetics, Aging, and Longevity in Model Organisms
• Share to Reproductive Biology and Fertility