Article
PROS-1/Prospero Is a Major Regulator of the Glia-Specific Secretome Controlling Sensory-Neuron Shape and Function in C. elegans.
Cell reports - 19 Apr 2016
Wallace Sean W, Singhvi Aakanksha, Liang Yupu, Lu Yun, Shaham Shai
Abstract excerpt
Sensory neurons are an animal's gateway to the world, and their receptive endings, the sites of sensory signal transduction, are often associated with glia. Although glia are known to promote sensory-neuron functions, the molecular bases of these interactions are poorly explored. Here, we describe a post-developmental glial role for the PROS-1/Prospero/PROX1 homeodomain protein in sensory-neuron function in C....
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cell Lineage
- Cell Shape
- Cellular Microenvironment
- Embryo, Nonmammalian
- Gene Deletion
- Gene Expression Regulation, Developmental
- Genes, Helminth
- Homeodomain Proteins
- Membrane Proteins
- Mutation