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Article

Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data.

Antimicrobial agents and chemotherapy - 1 Jun 2016

Kos Veronica N, McLaughlin Robert E, Gardner Humphrey A

Abstract excerpt

Ceftazidime is one of the few cephalosporins with activity against Pseudomonas aeruginosa Using whole-genome comparative analysis, we set out to determine the prevalent mechanism(s) of resistance to ceftazidime (CAZ) using a set of 181 clinical isolates. These isolates represented various multilocus sequence types that consisted of both ceftazidime-susceptible and -resistant populations. A presumptive resistance...

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Identifiers

PMID: 27067331
DOI: 10.1128/AAC.03113-15
PMCID: PMC4879354

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