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Article

Impact of dioxins on antipyrine metabolism in firefighters.

Toxicology letters - 27 May 2016

Chernyak Yury I, Merinova Alla P, Shelepchikov Andrey A, Kolesnikov Sergey I, Grassman Jean A

Abstract excerpt

Antipyrine (AP) metabolism was used to assess factors associated with the activity of hepatic oxidative enzymes in firefighters. Emphasis was placed on 3-hydroxymethylantipyrine (3HMAP), the metabolite with the greatest dependence on dioxin-inducible cytochrome P4501A2 (CYP1A2) activity. AP urinary metabolites were measured by HPLC in 38 male subjects from Eastern Siberia. Subjects were divided into three groups...

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Identifiers

PMID: 27067104
DOI: 10.1016/j.toxlet.2016.04.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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