Article
Association of Single Nucleotide Polymorphisms in the Apoptosis-Related Genes TP63 and CD40 with Risk for Lung Cancer in a Chinese Han Population.
The Tohoku journal of experimental medicine - 1 Apr 2016
Tang WenJun, Xue Li, Yan QiXing, Cai ShaoXi, Bai YuJie, Lin Li, Lin BiLin, Huang MingLong, Yi GuoHui, Li Hui
Abstract excerpt
Apoptosis plays a critical role in tumorigenesis. TP63 inhibits the pro-apoptosis function of TP53, and CD40 increases expression of anti-apoptotic proteins. Two single nucleotide polymorphisms (SNPs), rs6790167 (g243059A>G) in intron 9 of TP63 and rs1535045 (g6194C>T) in intron 1 of CD40 respectively, may affect the susceptibility of lung cancer. To evaluate the association of these SNPs with lung cancer, we...
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