Article
Genetic variant in TP63 on locus 3q28 is associated with risk of lung adenocarcinoma among never-smoking females in Asia.
Human genetics - 1 Jul 2012
Hosgood H Dean, Wang Wen-Chang, Hong Yun-Chul, Wang Jiu-Cun, Chen Kexin, Chang I-Shou, Chen Chien-Jen, Lu Daru, Yin Zhihua, Wu Chen, Zheng Wei, Qian Biyun, Park Jae Yong, Kim Yeul Hong, Chatterjee Nilanjan, Chen Ying, Chang Gee-Chen, Hsiao Chin-Fu, Yeager Meredith, Tsai Ying-Huang, Wei Hu, Kim Young Tae, Wu Wei, Zhao Zhenhong, Chow Wong-Ho, Zhu Xiaoling, Lo Yen-Li, Sung Sook Whan, Chen Kuan-Yu, Yuenger Jeff, Kim Joo Hyun, Huang Liming, Chen Ying-Hsiang, Gao Yu-Tang, Kim Jin Hee, Huang Ming-Shyan, Jung Tae Hoon, Caporaso Neil, Zhao Xueying, Huan Zhang, Yu Dianke, Kim Chang Ho, Su Wu-Chou, Shu Xiao-Ou, Kim In-San, Bassig Bryan, Chen Yuh-Min, Cha Sung Ick, Tan Wen, Chen Hongyan, Yang Tsung-Ying, Sung Jae Sook, Wang Chih-Liang, Li Xuelian, Park Kyong Hwa, Yu Chong-Jen, Ryu Jeong-Seon, Xiang Yongbing, Hutchinson Amy, Kim Jun Suk, Cai Qiuyin, Landi Maria Teresa, Lee Kyoung-Mu, Hung Jen-Yu, Park Ju-Yeon, Tucker Margaret, Lin Chien-Chung, Ren Yangwu, Perng Reury-Perng, Chen Chih-Yi, Jin Li, Chen Kun-Chieh, Li Yao-Jen, Chiu Yu-Fang, Tsai Fang-Yu, Yang Pan-Chyr, Fraumeni Joseph F, Seow Adeline, Lin Dongxin, Zhou Baosen, Chanock Stephen, Hsiung Chao Agnes, Rothman Nathaniel, Lan Qing
Abstract excerpt
A recent genome-wide association study (GWAS) of subjects from Japan and South Korea reported a novel association between the TP63 locus on chromosome 3q28 and risk of lung adenocarcinoma (p = 7.3 × 10(-12)); however, this association did not achieve genome-wide significance (p ≤ 10(-7)) among never-smoking males or females. To determine if this association with lung cancer risk is independent of tobacco use, we...
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