Mutation‐Specific Phenotypes in hiPSC‐Derived Cardiomyocytes Carrying Either Myosin‐Binding Protein C Or <i>α</i>‐Tropomyosin Mutation for Hypertrophic Cardiomyopathy

Abstract excerpt

Hypertrophic cardiomyopathy (HCM) is a genetic cardiac disease, which affects the structure of heart muscle tissue. The clinical symptoms include arrhythmias, progressive heart failure, and even sudden cardiac death but the mutation carrier can also be totally asymptomatic. To date, over 1400 mutations have been linked to HCM, mostly in genes encoding for sarcomeric proteins. However, the pathophysiological...

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