Article
Image-based computational quantification and visualization of genetic alterations and tumour heterogeneity.
Scientific reports - 7 Apr 2016
Zhong Qing, Rüschoff Jan H, Guo Tiannan, Gabrani Maria, Schüffler Peter J, Rechsteiner Markus, Liu Yansheng, Fuchs Thomas J, Rupp Niels J, Fankhauser Christian, Buhmann Joachim M, Perner Sven, Poyet Cédric, Blattner Miriam, Soldini Davide, Moch Holger, Rubin Mark A, Noske Aurelia, Rüschoff Josef, Haffner Michael C, Jochum Wolfram, Wild Peter J
Abstract excerpt
Recent large-scale genome analyses of human tissue samples have uncovered a high degree of genetic alterations and tumour heterogeneity in most tumour entities, independent of morphological phenotypes and histopathological characteristics. Assessment of genetic copy-number variation (CNV) and tumour heterogeneity by fluorescence in situ hybridization (ISH) provides additional tissue morphology at single-cell...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.