Article
BRCA1 Gene Mutations and Influence of Chemotherapy on Autophagy and Apoptotic Mechanisms in Egyptian Breast Cancer Patients.
Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2016
Abdel-Mohsen Mohamed Ahmed, Ahmed Omiama Ali, El-Kerm Yasser Mostafa
Abstract excerpt
BACKGROUND: It is well established that mutations in the BRCA1 gene are a major risk factor for breast cancer. Induction of cancer cell death and inhibition of survival are the main principles of cancer therapy. In this context, autophagy may have dual roles in cancer, acting on the one hand as a tumor suppressor and on the other as a mechanism of cell survival that can promote the growth of established tumors....
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