Somatic JAK-2 V617F Mutational Analysis in Polycythemia Rubra Vera: a Tertiary Care Center Experience.

doi:10.7314/apjcp.2016.17.3.1053

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Article

Somatic JAK-2 V617F Mutational Analysis in Polycythemia Rubra Vera: a Tertiary Care Center Experience.

Asian Pacific journal of cancer prevention : APJCP - 1 Jan 2016

Sultan Sadia, Irfan Syed Mohammed, Khan Sadia Rashid

Abstract excerpt

BACKGROUND: Polycythemia rubra vera (PV), being a primary polycythemia, is caused by neoplastic proliferation of erythroid, megakaryocytic and granulocytic lineages which result in panmyelosis. PV patients have a somatic acquired mutation in the Janus kinase (JAK2) pathway, rendering cell proliferation independent of the normal regulatory mechanisms that regulate erythropoiesis. The rational of this study was to...

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Identifiers

PMID: 27039724
DOI: 10.7314/apjcp.2016.17.3.1053

Genes

JAK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.