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Article

[Assessment of applicability of archived cytological lung cancer specimens for molecular genetic analysis].

Voprosy onkologii - 1 Jan 2015

Mityushkina N V, Ievleva A G, Poltoratsky A N, Ivantsov A O, Budovsky A I, Novik V I, Imyanitov E N

Abstract excerpt

Molecular genetic analysis of lung tumors is often essential for the proper choice of therapy. EGFR mutation is a well-known marker of sensitivity to gefitinib, erlotinib and afatinib; ALK-translocations make tumor sensitive to several ALK inhibitors; low intratumoral expression of DNA repair genes (ERCC1, BRCA1, etc.) may increase the therapeutic index of platinum-based drugs. Usually these markers are evaluated...

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Source

Identifiers

PMID: 26995989

Genes

ALK
EGFR
BRCA1
ERCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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