Article
The incidence of leukaemia in women with BRCA1 and BRCA2 mutations: an International Prospective Cohort Study.
British journal of cancer - 10 May 2016
Iqbal Javaid, Nussenzweig Andre, Lubinski Jan, Byrski Tomasz, Eisen Andrea, Bordeleau Louise, Tung Nadine M, Manoukian Siranoush, Phelan Catherine M, Sun Ping, Narod Steven A
Abstract excerpt
BACKGROUND: Germline mutations in BRCA1 and BRCA2 increase the susceptibility to develop breast and ovarian cancers as well as increase the risk of some other cancers. Primary objective was to estimate the risk of leukaemia in BRCA1 and BRCA2 mutation carriers. METHODS: We followed 7243 women with a BRCA1 or a BRCA2 mutation for incident cases of leukaemia. We used the standardised incidence ratio (SIR) to...
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