Article
[Functional properties of dopaminergic neurons obtained from fibroblasts of a patient with PARK2 form of Parkinson's disease].
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova - 1 Jan 2015
Konovalova Е V, Ivashkin Е G, Lopachev А V, Lopacheva О М, Komissarov А А, Grivennikov I А, Novosadova Е V, Dashynimaev E B, Fedotova Е Yu, Illarioshkin S N
Abstract excerpt
OBJECTIVE: To carry out a functional analysis of dopamine transporter (DAT) in autosomal recessive Parkinson's disease caused by mutations in the PARK2 gene. MATERIAL AND METHODS: Cultures of dopaminergic neurons were obtained from fibroblasts of a patient with PARK2 form of Parkinson's disease and a healthy donor with the use of the cell reprogramming technology. DAT expression in both cell cultures was assessed...
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