Article
CC chemokine receptor 5 Δ32 polymorphism: association analysis and allele distribution among cutaneous leishmaniasis patients from Pakistan.
Journal of cutaneous pathology - 1 Jul 2016
Sophie Mariam, Hameed Abdul, Muneer Akhtar, Samdani Azam J, Saleem Saima, Azhar Abid
Abstract excerpt
BACKGROUND: Human immunodeficiency virus (HIV)/leishmaniasis coinfection is a matter of deep concern worldwide. CC chemokine receptor 5 (CCR5) functions as a co-receptor for HIV entry into host immune cells with an elevated expression observed during leishmaniasis, promoting parasite persistence. A 32 bp deletion (Δ32) in the CCR5 gene provides protection against HIV infection and increased resistance to...
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