Article
International Genome-Wide Association Study Consortium Identifies Novel Loci Associated With Blood Pressure in Children and Adolescents.
Circulation. Cardiovascular genetics - 1 Jun 2016
Parmar Priyakumari Ganesh, Taal H Rob, Timpson Nicholas J, Thiering Elisabeth, Lehtimäki Terho, Marinelli Marcella, Lind Penelope A, Howe Laura D, Verwoert Germaine, Aalto Ville, Uitterlinden Andre G, Briollais Laurent, Evans Dave M, Wright Margie J, Newnham John P, Whitfield John B, Lyytikäinen Leo-Pekka, Rivadeneira Fernando, Boomsma Dorrett I, Viikari Jorma, Gillman Matthew W, St Pourcain Beate, Hottenga Jouke-Jan, Montgomery Grant W, Hofman Albert, Kähönen Mika, Martin Nicholas G, Tobin Martin D, Raitakari Ollie, Vioque Jesus, Jaddoe Vincent W V, Jarvelin Marjo-Riita, Beilin Lawrence J, Heinrich Joachim, van Duijn Cornelia M, Pennell Craig E, Lawlor Debbie A, Palmer Lyle J
Abstract excerpt
BACKGROUND: Our aim was to identify genetic variants associated with blood pressure (BP) in childhood and adolescence. METHODS AND RESULTS: Genome-wide association study data from participating European ancestry cohorts of the Early Genetics and Lifecourse Epidemiology (EAGLE) Consortium was meta-analyzed across 3 epochs; prepuberty (4-7 years), puberty (8-12 years), and postpuberty (13-20 years). Two novel loci...
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