Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation.

doi:10.3233/JAD-151200

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Article

Metformin Facilitates Amyloid-β Generation by β- and γ-Secretases via Autophagy Activation.

Journal of Alzheimer's disease : JAD - 1 Jan 2016

Son Sung Min, Shin Hong-Joon, Byun Jayoung, Kook Sun Young, Moon Minho, Chang Yu Jin, Mook-Jung Inhee

Abstract excerpt

The evidence of strong pathological associations between type 2 diabetes and Alzheimer's disease (AD) has increased in recent years. Contrary to suggestions that anti-diabetes drugs may have potential for treating AD, we demonstrate here that the insulin sensitizing anti-diabetes drug metformin (Glucophage®) increased the generation of amyloid-β (Aβ), one of the major pathological hallmarks of AD, by promoting β-...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 26967226
DOI: 10.3233/JAD-151200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.