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Modeling of drug-mediated CYP3A4 induction by using human iPS cell-derived enterocyte-like cells

8 Mar 2016

Abstract excerpt

Many drugs have potential to induce the expression of drug-metabolizing enzymes, particularly cytochrome P450 3A4 (CYP3A4), in small intestinal enterocytes. Therefore, a model that can accurately evaluate drug-mediated CYP3A4 induction is urgently needed. In this study, we overlaid Matrigel on the human induced pluripotent stem cells-derived enterocyte-like cells (hiPS-ELCs) to generate the mature hiPS-ELCs that...

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PMID: 26966071
DOI: 10.1016/j.bbrc.2016.03.012

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