Article
Efficient and biologically relevant consensus strategy for Parkinson's disease gene prioritization.
BMC medical genomics - 9 Mar 2016
Cruz-Monteagudo Maykel, Borges Fernanda, Paz-Y-Miño Cesar, Cordeiro M Natália D S, Rebelo Irene, Perez-Castillo Yunierkis, Helguera Aliuska Morales, Sánchez-Rodríguez Aminael, Tejera Eduardo
Abstract excerpt
BACKGROUND: The systemic information enclosed in microarray data encodes relevant clues to overcome the poorly understood combination of genetic and environmental factors in Parkinson's disease (PD), which represents the major obstacle to understand its pathogenesis and to develop disease-modifying therapeutics. While several gene prioritization approaches have been proposed, none dominate over the rest. Instead,...
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