Article
[Research Progress of Targeted Therapy for BRAF Mutation in Advanced Non-small Cell Lung Cancer].
Zhongguo fei ai za zhi = Chinese journal of lung cancer - 20 Aug 2018
Liu Xia, Zhong Diansheng
Abstract excerpt
Targeted therapy is one of the major treatment modalities in advanced non-small cell lung cancer (NSCLC) with sensitive driver gene mutations. BRAF is considered a promising oncogenic driver in NSCLC after the discovery of epidermal growth factor receptor (EGFR) mutation, anaplastic lymphoma kinase (ALK) fusion and ROS1 rearrangement. BRAF V600E mutation accounts for more than half of BRAF mutations, which is a...
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