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Article

Next-generation genotyping of hypervariable loci in many individuals of a non-model species: technical and theoretical implications.

BMC genomics - 8 Mar 2016

Grogan Kathleen E, McGinnis Gwendolyn J, Sauther Michelle L, Cuozzo Frank P, Drea Christine M

Abstract excerpt

BACKGROUND: Across species, diversity at the Major Histocompatibility Complex (MHC) is critical to disease resistance and population health; however, use of MHC diversity to quantify the genetic health of populations has been hampered by the extreme variation found in MHC genes. Next generation sequencing (NGS) technology generates sufficient data to genotype even the most diverse species, but workflows for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26957424
DOI: 10.1186/s12864-016-2503-y
PMCID: PMC4782575

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