Article
Bioinformatic analyses in early host response to Porcine Reproductive and Respiratory Syndrome virus (PRRSV) reveals pathway differences between pigs with alternate genotypes for a major host response QTL.
BMC genomics - 8 Mar 2016
Schroyen Martine, Eisley Christopher, Koltes James E, Fritz-Waters Eric, Choi Igseo, Plastow Graham S, Guan Leluo, Stothard Paul, Bao Hua, Kommadath Arun, Reecy James M, Lunney Joan K, Rowland Robert R R, Dekkers Jack C M, Tuggle Christopher K
Abstract excerpt
BACKGROUND: A region on Sus scrofa chromosome 4 (SSC4) surrounding single nucleotide polymorphism (SNP) marker WUR10000125 (WUR) has been reported to be strongly associated with both weight gain and serum viremia in pigs after infection with PRRS virus (PRRSV). A proposed causal mutation in the guanylate binding protein 5 gene (GBP5) is predicted to truncate the encoded protein. To investigate transcriptional...
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